"Quinine, a medicine made from the bark of the cinchona ______ was for centuries the main treatment for malaria." Options: (A) tree (B) tree, (C) tree; (D) tree:
- The subject is "Quinine" and its verb is "was."
- "a medicine made from the bark of the cinchona tree" is extra information: the sentence still works without it.
- It opens with a comma after "Quinine," so it must close with a comma. A semicolon or colon would cut the subject off from its verb.
Answer: (B) tree,